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Hyperthermia Therapy of a Biological Tissue CFD Simulation

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One of the most effective methods in the treatment of cancer is the use of hyperthermia therapy, whereby the temperature is greatly increased by the application of ultrasound to the cancer tissue center.

This product includes a CFD simulation and training files using ANSYS Fluent software.

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Description

Problem Description for Hyperthermia Therapy

Common methods of cancer treatment include surgery, radiotherapy, and chemotherapy. These methods have disadvantages including aggressiveness, irreversibility, and side effects. Warming in Hyperthermia Therapy prevents oxygen and nutrients from getting into the unhealthy tissue; in this way, proteins within the tissue change nature and can surround the cancer cells. This makes it possible for the immune system to identify cancer cells.

The present study examined blood flow in capillaries passing through a tissue containing cancerous tumors and using Hyperthermia Therapy. For this purpose, we assume a spherical space to be an example of a healthy body tissue or cell in which blood flows at a very slow rate. There are several veins within this tissue. The vein structure of cells and tissues of the body are like bushes. To simplify the problem, we assumed that all the veins, align uniformly in the tissue (X axis). As the blood flow passes through the spaces within the tissue, the whole tissue can be considered a porous medium.

There are four spherical cancerous tumors of different diameters at the center of this tissue and on the surface of the veins as Biological Tissue. In fact, the thermophysical properties of a healthy tissue differ from those of cancer cells, but to simplify this, we assume the thermophysical properties of the healthy tissue similar to the unhealthy cells. Every cancerous tissues is a heat source with heat energy per unit of volume to cause heat transfer and thereby significantly increase blood flow. The purpose of this study is to investigate the response of blood vessels and body tissues to this heat.

Assumption for Biological Tissue Hyperthermia Therapy

Hyperthermia Therapy CFD Simulation of the problem is transient (unsteady).

We use pressure-based solver for the simulation.

We do not consider the effect of the earth’s gravity on the blood flow.

Geometry & Mesh

Design Modeler software, design the 3-D model of Biological Tissue. The present model comprises a cylindrical tube as the capillary, four spherical blood vessels attached to the capillary as tumors, and a spherical space for intra-arterial blood flow around the vein, which has a slower flow rate than flow Inside the capillaries. Spherical tissues around the capillary have different radius (3, 5, 6, and 7.5 mm). The outer sphere is also considered as the space for blood flow within the tissue and around the capillary, which contains two input and output hemispheres.

Meshing was performed by ANSYS Meshing software. The present grid was unstructured with 717087 cells.

 

All files, including Geometry, Mesh, Case & Data, are available in Simulation File. By the way, Training File presents how to solve the problem and extract all desired results.

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